Decreased GABAA receptor subunit mRNA concentrations following chronic lorazepam administration
نویسندگان
چکیده
منابع مشابه
Plasma concentrations and clinical effects of lorazepam after oral administration.
The relation between plasma concentrations and properties of lorazepam administered orally as premedication was studied in patients undergoing minor surgery. The drug was found to be reliably absorbed in most subjects producing plasma concentrations similar to those reported after injection. Effective concentrations were obtained within 30-60 min, maintained for 4-6 h and were closely related t...
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An increase in the activity of brain stem locus coeruleus noradrenergic neurons has been hypothesised to be a major factor accounting for opiate withdrawal symptoms. These neurons are under GABAergic inhibition. Their GABAA receptors have unique pharmacological properties, most likely due to the enriched expression of GABAA receptor subtypes containing novel å and è subunits. Using in situ hybr...
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The magnocellular hypothalamic neurons exhibit a substantial degree of structural and functional plasticity over the time of pregnancy, parturition, and lactation. This study has used in situ hybridization techniques to examine whether the content of alpha 1, alpha 2, beta 2, gamma 2 GABAA receptor subunit mRNAs expressed by these cells fluctuates over this period. A process of regional, follow...
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Functionally, GABAA receptor (GABAR)-mediated inhibition can be classified as phasic (synaptic) and tonic (extrasynaptic). The GABARs underlying tonic inhibition assemble from different subunits than those responsible for phasic inhibition. We wanted to assess the excitability of hippocampal pyramidal cell (PC) networks following a selective impairment of tonic inhibition. This is difficult to ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1991
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1991.tb09781.x